From the Egyptian desert to deep below the polar ice caps, the elite G.I. JOE team uses the latest in next-generation spy and military equipment to fight the corrupt arms dealer Destro and the growing threat of the mysterious Cobra organization to prevent them from plunging the world into chaos.

近未来，武器研发集团MARS的创始人詹姆斯发明了名为“纳罗脉”的微型机器人，该机器人可以在很短时间内吞噬掉挡路的敌人，威力巨大。北大西洋公约组织（NATO）武器研究所对此颇感兴趣，向MARS集团购买了四颗纳罗脉弹头。运送途中，护卫队遭到一伙高科技武装分子的袭击。在弹头即将被抢去之际，另一组神秘人马阻止了武装分子的计划，并解救了护卫队仅剩的两名成员公爵和开伞索。解救公爵的正是霍克将军所统率的特种部队，公爵和开伞索请求加入该部队，以血前耻。另一方面，阴谋夺取弹头的幕后黑手正是麦库伦，他企图从NATO榨取巨额资金以支持他的研究，继而实现称霸世界的野心。一场正邪较量就此展开。

An elite G.I. Joe team confronts a Cobra force in Springfield, USA to rescue a comrade and deal with a traitor.

An elite G.I. Joe team confronts a Cobra force in Springfield, USA to rescue a comrade and deal with a traitor.

Framed for crimes against the country, the G.I. Joe team is terminated by Presidential order. This forces the G.I. Joes into not only fighting their mortal enemy Cobra; they are forced to contend with threats from within the government that jeopardize their very existence.

SIGMA 6 is the code name for a group of highly trained covert special mission operatives. Duke, Snake Eyes, Heavy Duty, Scarlett, Long Range and Tunnel Rat - who use high-tech, state-of-the-art gear along with their other hero skills to go up against the forces of evil.

After yet another defeat inflicted by G.I. Joe, the immediate subordinates of Cobra's leader, Cobra Commander, have finally come to the end of their patience with his apparent incompetence and his inability to achieve real victories. The leader of the research and interrogations wing, Dr. Mindbender, receives a dream showing the solution. His plan is to collect the genetic material of great warriors and military leaders to create a composite clone that would be the perfect leader for Cobra. Now they set out to put this scheme into motion, and G.I. Joe has very little time to learn of this plot before Cobra becomes that much more a dire threat to the world.

While stationed in Asia, six American G.I.'s witness the secret ritual of Lamians (worshipers of women who can change into serpents). When discovered by the cult, the High Lamian Priest vows that "the Cobra Goddess will avenge herself". Once back in the United States, a mysterious woman enters into their lives and accidents begin to happen. The shadow of a cobra is seen just before each death.

Maxime Salomon, a rebellious policewoman, takes under her wing four young people with troubled pasts.

Before he hits the stage on his sold-out Happiness Begins tour, Joe Jonas will experience each city like a true native in his very on travel show from Quibi – as a local guides him through each destination.